The Mississippi State Department of Health says two Caledonia High School students had an allergic reaction to the H1N1 vaccination.
Six other students developed shortness of breath after the shot but didn't exhibit the normal allergic reaction symptoms.
All are reported to be doing well after they were taken to Baptist Golden Triangle.
A spokeswoman for the Department of Health says the agency is looking into what happened at the school.
Lowndes County Schools Superintendent Mike Halford says the vaccinations have been suspended at Caledonia School. The middle school and elementary were also set to receive the vaccination.
Halford says some students checked out of school after not feeling well after receiving the shot.
No health problems have reported at New Hope School or at any Columbus schools, where students are also receiving the shot.
The Department of Health has been in contact with Baptist Golden Triangle doctors and nurses, along with an instructor from the MUW School of Nursing who were administering the shots.
M.S.D.H. says it isn't abnormal for some people to develop allergic reactions to the shots, and they're encouraging the public to get the H1N1 vaccination.